Using RNA inverse folding to identify IRES-like structural subdomains
نویسندگان
چکیده
منابع مشابه
Inverse folding of RNA
The aim of the inverse folding problem for RNA is, given a target structure like e.g. the one depicted in Fig. 1, find a sequence that folds into this structure. In this project we will exclusively focus on the secondary structure. The main driving force behind RNA structure formation is the creation of base pairs similar to the ones observed in the DNA double helical structure. In RNA thymine ...
متن کاملInverse folding of RNA II
In the Oxford Summer School in Computational Biology 2011, one of the projects was aimed at creating an improved method for inverse RNA folding based on a genetic algorithm (GA) approach. This turned out to be sufficiently successful [16] and inspiring, that we will extend on it in this year’s summer school. The inverse RNA folding problem consists of finding an RNA sequence that, as a molecule...
متن کاملINFO-RNA - a fast approach to inverse RNA folding
MOTIVATION The structure of RNA molecules is often crucial for their function. Therefore, secondary structure prediction has gained much interest. Here, we consider the inverse RNA folding problem, which means designing RNA sequences that fold into a given structure. RESULTS We introduce a new algorithm for the inverse folding problem (INFO-RNA) that consists of two parts; a dynamic programmi...
متن کاملMODENA: a multi-objective RNA inverse folding
Artificially synthesized RNA molecules have recently come under study since such molecules have a potential for creating a variety of novel functional molecules. When designing artificial RNA sequences, secondary structure should be taken into account since functions of noncoding RNAs strongly depend on their structure. RNA inverse folding is a methodology for computationally exploring the RNA ...
متن کاملNew scoring system to identify RNA G-quadruplex folding
G-quadruplexes (G4s) are non-canonical structures involved in many important cellular processes. To date, the prediction of potential G-quadruplex structures (PG4s) has been based almost exclusively on the sequence of interest agreeing with the algorithm Gx-N-1-7-Gx-N1-7-Gx-N1-7-Gx (where x ≥ 3 and N = A, U, G or C). However, many sequences agreeing with this algorithm do not form G4s and are c...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2013
ISSN: 1547-6286,1555-8584
DOI: 10.4161/rna.26994